Defects in interstrand cross-link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin

The anticancer drug cisplatin reacts with DNA leading to the formation of interstrand and intrastrand cross-links that are the critical cytotoxic lesions. In contrast to cells bearing mutations in other components of the nucleotide excision repair apparatus (XPB, XPD, XPG and CSB), cells defective f...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	De Silva, Inusha U., McHugh, Peter J., Clingen, Peter H., Hartley, John A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137407/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12202770/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf479
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