Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's Disease: a cross-sectional study

BACKGROUND: The presence of the apolipoprotein E (APOE) ε4 allele is a major risk factor for the development of Alzheimer's disease (AD), and has been associated with metabolic brain changes several years before the onset of typical AD symptoms. Functional MRI (fMRI) is a brain imaging techniqu...

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Bibliographic Details
Main Authors: Trivedi, Mehul A, Schmitz, Taylor W, Ries, Michele L, Torgerson, Britta M, Sager, Mark A, Hermann, Bruce P, Asthana, Sanjay, Johnson, Sterling C
Format: Artigo
Language:Inglês
Published: BioMed Central 2006
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1373642/
https://ncbi.nlm.nih.gov/pubmed/16412236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-4-1
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