Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules

Intracellular protein interaction domains are essential for eukaryotic signaling. In T cells, the CD2BP2 adaptor binds two membrane-proximal proline-rich motifs in the CD2 cytoplasmic tail via its GYF domain, thereby regulating interleukin-2 production. Here we present the structure of the GYF domai...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	EMBO J
Hauptverfasser:	Freund, Christian, Kühne, Ronald, Yang, Hailin, Park, Sunghyouk, Reinherz, Ellis L., Wagner, Gerhard
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2002
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137194/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12426371/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf602
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!