A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling

Specialized neurons throughout the developing central nervous system secrete Reelin, which binds to ApoE receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR), triggering a signal cascade that guides neurons to their correct position. Binding of Reelin to ApoER2 and VLDLR induces pho...

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Autores principales: Koch, Stefanie, Strasser, Vera, Hauser, Christoph, Fasching, Daniela, Brandes, Christian, Bajari, Tarek M., Schneider, Wolfgang J., Nimpf, Johannes
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2002
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC137191/
https://ncbi.nlm.nih.gov/pubmed/12426372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf599
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