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Solution structure of the hydroperoxide of Co(III) phleomycin complexed with d(CCAGGCCTGG)(2): evidence for binding by partial intercalation
The bleomycins (BLMs) are natural products that in the presence of iron and oxygen bind to and cause single-strand and double-strand cleavage of DNA. The mode(s) of binding of the FeBLMs that leads to sequence-specific cleavage at pyrimidines 3′ to guanines and chemical-specific cleavage at the C-4′...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC137157/ https://ncbi.nlm.nih.gov/pubmed/12433991 |
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