The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells

To determine mechanistically how siRNAs mediate transcriptional gene silencing (TGS) in human cells, we have measured histone methylation at targeted promoters, the dependency on active transcription, and whether or not both strands of the siRNA are required for siRNA-mediated TGS. We report here th...

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Main Authors: WEINBERG, MARC S., VILLENEUVE, LOUISA M., EHSANI, ALI, AMARZGUIOUI, MOHAMMED, AAGAARD, LARS, CHEN, ZHAO-XIA, RIGGS, ARTHUR D., ROSSI, JOHN J., MORRIS, KEVIN V.
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2006 by RNA Society 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370905/
https://ncbi.nlm.nih.gov/pubmed/16373483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2235106
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