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The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro
The eukaryotic initiation factor eIF4E binds the mRNA 5′ cap structure and has a central role during translational initiation. eIF4E and the mechanisms to control its activity have oncogenic properties and thus have become targets for anticancer drug development. A recent study (Kentsis et al. 2004)...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Copyright 2005 by RNA Society
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370834/ https://ncbi.nlm.nih.gov/pubmed/16131589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2132505 |
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