The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro

The eukaryotic initiation factor eIF4E binds the mRNA 5′ cap structure and has a central role during translational initiation. eIF4E and the mechanisms to control its activity have oncogenic properties and thus have become targets for anticancer drug development. A recent study (Kentsis et al. 2004)...

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Hauptverfasser: WESTMAN, BELINDA, BEEREN, LISA, GRUDZIEN, EWA, STEPINSKI, JANUSZ, WORCH, REMIGIUSZ, ZUBEREK, JOANNA, JEMIELITY, JACEK, STOLARSKI, RYSZARD, DARZYNKIEWICZ, EDWARD, RHOADS, ROBERT E., PREISS, THOMAS
Format: Artigo
Sprache:Inglês
Veröffentlicht: Copyright 2005 by RNA Society 2005
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370834/
https://ncbi.nlm.nih.gov/pubmed/16131589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2132505
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