RNA hydrolysis and inhibition of translation by a Co(III)–cyclen complex

Metal ion-chelator catalysts based on main-group, lanthanide, or transition metal complexes have been developed as nonenzymatic alternatives for the hydrolysis of the phosphodiester bonds in DNA and RNA. Cobalt (III), with its high-charge density, is known for its ability to hydrolyze phosphodiester...

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Main Authors: DELEHANTY, JAMES B., STUART, THOMAS C., KNIGHT, D. ANDREW, GOLDMAN, ELLEN R., THACH, DZUNG C., BONGARD, JASON E., CHANG, EDDIE L.
Format: Artigo
Language:Inglês
Published: Copyright 2005 by RNA Society 2005
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Method
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370767/
https://ncbi.nlm.nih.gov/pubmed/15840822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7156805
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