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Determinants of the inherent strength of human 5′ splice sites

We previously showed that the authentic 5′ splice site (5′ss) of the first exon in the human β-globin gene is intrinsically stronger than a cryptic 5′ss located 16 nucleotides upstream. Here we examined by mutational analysis the contribution of individual 5′ss nucleotides to discrimination between...

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Autors principals: ROCA, XAVIER, SACHIDANANDAM, RAVI, KRAINER, ADRIAN R.
Format: Artigo
Idioma:Inglês
Publicat: Copyright 2005 by RNA Society 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370755/
https://ncbi.nlm.nih.gov/pubmed/15840817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2040605
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