The crystal structure of a high affinity RNA stem-loop complexed with the bacteriophage MS2 capsid: Further challenges in the modeling of ligand–RNA interactions

We have determined the structure to 2.8 Å of an RNA aptamer (F5), containing 2′-deoxy-2-aminopurine (2AP) at the −10 position, complexed with MS2 coat protein by soaking the RNA into precrystallised MS2 capsids. The −10 position of the RNA is an important determinant of binding affinity for coat pro...

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Bibliografiska uppgifter
Huvudupphovsmän: HORN, WILF T., CONVERY, MÁIRE A., STONEHOUSE, NICOLA J., ADAMS, CHRIS J., LILJAS, LARS, PHILLIPS, SIMON E.V., STOCKLEY, PETER G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Copyright 2004 by RNA Society 2004
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370665/
https://ncbi.nlm.nih.gov/pubmed/15496523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7710304
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