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The crystal structure of a high affinity RNA stem-loop complexed with the bacteriophage MS2 capsid: Further challenges in the modeling of ligand–RNA interactions
We have determined the structure to 2.8 Å of an RNA aptamer (F5), containing 2′-deoxy-2-aminopurine (2AP) at the −10 position, complexed with MS2 coat protein by soaking the RNA into precrystallised MS2 capsids. The −10 position of the RNA is an important determinant of binding affinity for coat pro...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Copyright 2004 by RNA Society
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370665/ https://ncbi.nlm.nih.gov/pubmed/15496523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7710304 |
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