Efficient Integration of Recombinant Adeno-Associated Virus DNA Vectors Requires a p5-rep Sequence in cis

The initial aim of this study was to combine attributes of adeno-associated virus (AAV) and adenovirus (Ad) gene therapy vectors to generate an Ad-AAV hybrid vector allowing efficient site-specific integration with Ad vectors. In executing our experimental strategy, we found that, in addition to the...

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Detalhes bibliográficos
Main Authors: Philpott, Nicola J., Giraud-Wali, Catherine, Dupuis, Carolyn, Gomos, Janette, Hamilton, Henry, Berns, Kenneth I., Falck-Pedersen, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC137060/
https://ncbi.nlm.nih.gov/pubmed/11991970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.11.5411-5421.2002
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