Zeptomole detection of a viral nucleic acid using a target-activated ribozyme

We describe a strategy for the ultra-sensitive detection of nucleic acids using “half” ribozymes that are devoid of catalytic activity unless completed by a trans-acting target nucleic acid. The half-ribozyme concept was initially demonstrated using a construct derived from a multiple turnover Class...

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Detaylı Bibliyografya
Asıl Yazarlar: VAISH, NARENDRA K., JADHAV, VASANT R., KOSSEN, KARL, PASKO, CHRISTOPHER, ANDREWS, LORI E., MCSWIGGEN, JAMES A., POLISKY, BARRY, SEIWERT, SCOTT D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Copyright 2003 by RNA Society 2003
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370471/
https://ncbi.nlm.nih.gov/pubmed/12923255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5760703
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