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High-affinity hnRNP A1 binding sites and duplex-forming inverted repeats have similar effects on 5' splice site selection in support of a common looping out and repression mechanism.

High-affinity binding sites for the hnRNP A1 protein stimulate the use of a distal 5' splice site in mammalian pre-mRNAs. Notably, strong A1-mediated shifts in splice site selection are not accompanied by equivalent changes in the assembly of U1 snRNP-containing complexes on competing 5' s...

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Bibliografiske detaljer
Main Authors: Nasim, Faiz-Ul Hassan, Hutchison, Stephen, Cordeau, Mélanie, Chabot, Benoit
Format: Artigo
Sprog:Inglês
Udgivet: 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370318/
https://ncbi.nlm.nih.gov/pubmed/12212851
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