Structural and functional properties of the HIV-1 RNA-tRNA(Lys)3 primer complex annealed by the nucleocapsid protein: comparison with the heat-annealed complex.

The conversion of the single-stranded RNA genome into double-stranded DNA by virus-coded reverse transcriptase (RT) is an essential step of the retrovirus life cycle. In human immunodeficiency virus type 1 (HIV-1), RT uses the cellular tRNA(Lys)3 to initiate the (-) strand DNA synthesis. Placement o...

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Detalhes bibliográficos
Main Authors: Brulé, Fabienne, Marquet, Roland, Rong, Liwei, Wainberg, Mark A, Roques, Bernard P, Le Grice, Stuart F J, Ehresmann, Bernard, Ehresmann, Chantal
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370235/
https://ncbi.nlm.nih.gov/pubmed/11873759
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