Cellular mutants define a common mRNA degradation pathway targeting cytokine AU-rich elements.

To functionally classify AU-rich elements (AREs) from six different cytokine mRNAs, we made use of two previously described HT1080-derived cellular mutants (slowA, slowC) that lack a function required for the rapid degradation of interleukin-3 (IL-3) mRNA. Here we show that the defect is specific fo...

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Bibliografiske detaljer
Main Authors: Stoecklin, G, Stoeckle, P, Lu, M, Muehlemann, O, Moroni, C
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370200/
https://ncbi.nlm.nih.gov/pubmed/11720287
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