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Altered discrimination of start codons and initiator tRNAs by mutant initiation factor 3.

IF3 is essential for ensuring the fidelity of the initiation step of translation in bacterial cells. Mutations at residues R99 and R131 in the C-terminal domain of the factor have previously been shown to increase initiation from the non-canonical GUA codon. Here we show that these mutant forms of I...

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Detalhes bibliográficos
Main Authors: O'Connor, M, Gregory, S T, Rajbhandary, U L, Dahlberg, A E
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370149/
https://ncbi.nlm.nih.gov/pubmed/11453069
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