The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export.

In metazoa, a subset of spliceosomal U snRNAs are exported from the nucleus after transcription. This export occurs in a large complex containing a U snRNA, the nuclear cap binding complex (CBC), the leucine-rich nuclear export signal receptor CRM1/Xpo1, RanGTP, and the recently identified phosphopr...

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Bibliographic Details
Main Authors: Segref, A, Mattaj, I W, Ohno, M
Format: Artigo
Language:Inglês
Published: 2001
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370092/
https://ncbi.nlm.nih.gov/pubmed/11333016
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