Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.

Although the primary structures of class 1 polypeptide release factors (RF1 and RF2 in prokaryotes, eRF1 in eukaryotes) are known, the molecular basis by which they function in translational termination remains obscure. Because all class 1 RFs promote a stop-codon-dependent and ribosome-dependent hy...

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Autori principali: Frolova, L Y, Tsivkovskii, R Y, Sivolobova, G F, Oparina, N Y, Serpinsky, O I, Blinov, V M, Tatkov, S I, Kisselev, L L
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1999
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369825/
https://ncbi.nlm.nih.gov/pubmed/10445876
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