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Genetically Stable Picornavirus Expression Vectors with Recombinant Internal Ribosomal Entry Sites

In many respects, picornaviruses are well suited for their proposed use as immunization vectors. However, their inherent genetic instability hinders application for prophylactic purposes. We demonstrate the improved expression and stability of a heterologous insert through a novel vector design stra...

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Bibliografiske detaljer
Main Authors: Dufresne, Andrew T., Dobrikova, Elena Y., Schmidt, Stacie, Gromeier, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC136971/
https://ncbi.nlm.nih.gov/pubmed/12163617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.17.8966-8972.2002
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