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A new strategy for introducing photoactivatable 4-thiouridine ((4S)U) into specific positions in a long RNA molecule.

We describe a new protocol, which does not require (4S)UpG, for introducing (4S)U into specific sites in a pre-mRNA substrate. A 5'-half and a full-length RNA are first synthesized by phage RNA polymerase. p(4S)Up, which is derived from (4S)UpU and can therefore be 32P-labeled, is then ligated...

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Detalles Bibliográficos
Main Authors: Yu, Y T, Steitz, J A
Formato: Artigo
Idioma:Inglês
Publicado: 1997
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369526/
https://ncbi.nlm.nih.gov/pubmed/9214662
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