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Diels-Alder cycloadditions in water for the straightforward preparation of peptide–oligonucleotide conjugates
The Diels-Alder reaction between diene-modified oligonucleotides and maleimide-derivatized peptides afforded peptide–oligonucleotide conjugates with high purity and yield. Synthesis of the reagents was easily accomplished by on-column derivatization of the corresponding peptides and oligonucleotides...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1369286/ https://ncbi.nlm.nih.gov/pubmed/16478710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnj020 |
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