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The Caenorhabditis elegans homologue of the proto-oncogene ect-2 positively regulates RAS signalling during vulval development

Guanine nucleotide exchange factors (GEFs) regulate the activity of small GTP-binding proteins in a variety of biological processes. We have identified a gain-of-function mutation in the Caenorhabditis elegans GEF ect-2, the homologue of the mammalian ect2 proto-oncogene that has an essential role d...

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Библиографические подробности
Главные авторы: Canevascini, Stefano, Marti, Mark, Fröhli, Erika, Hajnal, Alex
Формат: Artigo
Язык:Inglês
Опубликовано: 2005
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369209/
https://ncbi.nlm.nih.gov/pubmed/16270101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400574
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