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Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation
The ubiquitin ligase Cbl mediates ubiquitination of activated receptor tyrosine kinases (RTKs) and interacts with endocytic scaffold complexes, including CIN85/endophilins, to facilitate RTK endocytosis and degradation. Several mechanisms regulate the functions of Cbl to ensure the fine-tuning of RT...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1369112/ https://ncbi.nlm.nih.gov/pubmed/15962011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400453 |
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