Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation

The ubiquitin ligase Cbl mediates ubiquitination of activated receptor tyrosine kinases (RTKs) and interacts with endocytic scaffold complexes, including CIN85/endophilins, to facilitate RTK endocytosis and degradation. Several mechanisms regulate the functions of Cbl to ensure the fine-tuning of RT...

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Detalles Bibliográficos
Main Authors: Haglund, Kaisa, Schmidt, Mirko H H, Wong, Esther Sook Miin, Guy, Graeme R, Dikic, Ivan
Formato: Artigo
Idioma:Inglês
Publicado: 2005
Assuntos:
Scientific Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369112/
https://ncbi.nlm.nih.gov/pubmed/15962011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400453
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