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The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?
Histone acetylation regulates many chromosome functions, such as gene expression and chromosome segregation. Histone deacetylase inhibitors (HDACIs) induce growth arrest, differentiation and apoptosis of cancer cells ex vivo, as well as in vivo in tumour-bearing animal models, and are now undergoing...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1369099/ https://ncbi.nlm.nih.gov/pubmed/15940285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400441 |
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