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The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy?
Histone acetylation regulates many chromosome functions, such as gene expression and chromosome segregation. Histone deacetylase inhibitors (HDACIs) induce growth arrest, differentiation and apoptosis of cancer cells ex vivo, as well as in vivo in tumour-bearing animal models, and are now undergoing...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1369099/ https://ncbi.nlm.nih.gov/pubmed/15940285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400441 |
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