Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-X(L)

BACKGROUND: Pim-1, 2 and 3 are a group of enzymes related to the calcium calmodulin family of protein kinases. Over-expression of Pim-1 and Pim-2 in mice promotes the development of lymphomas, and up-regulation of Pim expression has been observed in several human cancers. RESULTS: Here we show that...

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Autors principals: Macdonald, Andrew, Campbell, David G, Toth, Rachel, McLauchlan, Hilary, Hastie, C James, Arthur, J Simon C
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2006
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1368972/
https://ncbi.nlm.nih.gov/pubmed/16403219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-7-1
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