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Evidence for pre-hepatic metabolism of oral cyclosporine in children.

1. The pharmacokinetics of cyclosporine were investigated before renal transplantation in 20 children aged 1.1 to 16.8 years. Cyclosporine was given as a single oral dose (10 mg kg-1) or as a 4 h i.v. infusion (3 mg kg-1). 2. The blood drug concentration was measured by both specific and nonspecific...

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Detalhes bibliográficos
Principais autores: Hoppu, K, Koskimies, O, Holmberg, C, Hirvisalo, E L
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1368609/
https://ncbi.nlm.nih.gov/pubmed/1958443
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