The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine, trimethadione and debrisoquine as model substrates.

Six healthy male subjects were given single oral doses of antipyrine (7 mg kg-1), trimethadione (4 mg kg-1) and debrisoquine (10 mg) before and during diltiazem treatment (30 mg three times daily orally for 8 days). Antipyrine clearance decreased from 33.7 +/- 9.1 to 22.5 +/- 4.9 ml min-1 (P less th...

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Bibliographic Details
Main Authors: Sakai, H, Kobayashi, S, Hamada, K, Iida, S, Akita, H, Tanaka, E, Uchida, E, Yasuhara, H
Format: Artigo
Language:Inglês
Published: 1991
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1368366/
https://ncbi.nlm.nih.gov/pubmed/2054276
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