Critical Role for Perforin-, Fas/FasL-, and TNFR1-Mediated Cytotoxic Pathways in Down-Regulation of Antigen-Specific T Cells during Persistent Viral Infection

Viral persistence following infection with invasive strains of lymphocytic choriomeningitis virus (LCMV) can be achieved by selective down-regulation of virus-specific T lymphocytes. High viral burden in the onset of infection drives responding cells into functional unresponsiveness (anergy) that ca...

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Bibliographic Details
Main Authors: Zhou, Shenghua, Ou, Rong, Huang, Lei, Moskophidis, Demetrius
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC136836/
https://ncbi.nlm.nih.gov/pubmed/11752172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.2.829-840.2002
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