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Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin.

Studies were performed in 13 healthy subjects to determine whether treatment with rifampicin results in induction of the metabolism of mephenytoin. Daily dosing with 600 mg rifampicin for 22 days caused a three to eightfold increase in the 0-8 h urinary R/S ratio of mephenytoin following oral admini...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhou, H H, Anthony, L B, Wood, A J, Wilkinson, G R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1990
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1368151/
https://ncbi.nlm.nih.gov/pubmed/2223426
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