Phorbol-12,13-dibutyrate antagonizes the α(1)-adrenoceptor-mediated positive inotropic effect in the rabbit ventricular myocardium

The phorbol ester phorbol-12,13-dibutyrate (PDBu) elicited a slight but significant positive inotropic effect (PIE) (10-100 nM) in the presence of a β-adrenoceptor antagonist (±)-bupranolol (300 nM). PDBu (10-1000 nM) inhibited the α(1)-adrenoceptor mediated PIE in a concentration-dependent manner,...

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Main Authors: Endoh, M., Otomo, J., Norota, I.
格式: Artigo
語言:Inglês
出版: 1990
主題:
Free Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1368109/
https://ncbi.nlm.nih.gov/pubmed/1980075
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