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Phorbol-12,13-dibutyrate antagonizes the α(1)-adrenoceptor-mediated positive inotropic effect in the rabbit ventricular myocardium
The phorbol ester phorbol-12,13-dibutyrate (PDBu) elicited a slight but significant positive inotropic effect (PIE) (10-100 nM) in the presence of a β-adrenoceptor antagonist (±)-bupranolol (300 nM). PDBu (10-1000 nM) inhibited the α(1)-adrenoceptor mediated PIE in a concentration-dependent manner,...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1990
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1368109/ https://ncbi.nlm.nih.gov/pubmed/1980075 |
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