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Evidence for Human Immunodeficiency Virus Type 1 Replication In Vivo in CD14(+) Monocytes and Its Potential Role as a Source of Virus in Patients on Highly Active Antiretroviral Therapy

In vitro studies show that human immunodeficiency virus type 1 (HIV-1) does not replicate in freshly isolated monocytes unless monocytes differentiate to monocyte-derived macrophages. Similarly, HIV-1 may replicate in macrophages in vivo, whereas it is unclear whether blood monocytes are permissive...

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Udgivet i:J Virol
Principais autores: Zhu, Tuofu, Muthui, David, Holte, Sarah, Nickle, David, Feng, Feng, Brodie, Scott, Hwangbo, Yon, Mullins, James I., Corey, Lawrence
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136806/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11752161/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.2.707-716.2002
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