Evidence for Human Immunodeficiency Virus Type 1 Replication In Vivo in CD14(+) Monocytes and Its Potential Role as a Source of Virus in Patients on Highly Active Antiretroviral Therapy

In vitro studies show that human immunodeficiency virus type 1 (HIV-1) does not replicate in freshly isolated monocytes unless monocytes differentiate to monocyte-derived macrophages. Similarly, HIV-1 may replicate in macrophages in vivo, whereas it is unclear whether blood monocytes are permissive...

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Detalhes bibliográficos
Main Authors: Zhu, Tuofu, Muthui, David, Holte, Sarah, Nickle, David, Feng, Feng, Brodie, Scott, Hwangbo, Yon, Mullins, James I., Corey, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136806/
https://ncbi.nlm.nih.gov/pubmed/11752161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.2.707-716.2002
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