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Live, Attenuated Simian Immunodeficiency Virus SIVmac-M4, with Point Mutations in the Env Transmembrane Protein Intracytoplasmic Domain, Provides Partial Protection from Mucosal Challenge with Pathogenic SIVmac251

Attenuated molecular clones of simian immunodeficiency virus (SIVmac) are important tools for studying the correlates of protective immunity to lentivirus infection in nonhuman primates. The most highly attenuated SIVmac mutants fail to induce disease but also fail to induce immune responses capable...

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Published in:J Virol
Main Authors: Shacklett, Barbara L., Shaw, Karen E. S., Adamson, Lou A., Wilkens, David T., Cox, Catherine A., Montefiori, David C., Gardner, Murray B., Sonigo, Pierre, Luciw, Paul A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2002
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136751/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12388697/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.22.11365-11378.2002
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