Live, Attenuated Simian Immunodeficiency Virus SIVmac-M4, with Point Mutations in the Env Transmembrane Protein Intracytoplasmic Domain, Provides Partial Protection from Mucosal Challenge with Pathogenic SIVmac251

Attenuated molecular clones of simian immunodeficiency virus (SIVmac) are important tools for studying the correlates of protective immunity to lentivirus infection in nonhuman primates. The most highly attenuated SIVmac mutants fail to induce disease but also fail to induce immune responses capable...

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Autors principals: Shacklett, Barbara L., Shaw, Karen E. S., Adamson, Lou A., Wilkens, David T., Cox, Catherine A., Montefiori, David C., Gardner, Murray B., Sonigo, Pierre, Luciw, Paul A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC136751/
https://ncbi.nlm.nih.gov/pubmed/12388697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.22.11365-11378.2002
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