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The First HxRxG Motif in Simian Immunodeficiency Virus mac239 Vpr Is Crucial for G(2)/M Cell Cycle Arrest
The highly conserved Vpr protein mediates cell cycle arrest, transcriptional transactivation, and nuclear import of the preintegration complex in human immunodeficiency virus type 1. To identify functional domains in simian immunodeficiency virus (SIV) mac239 Vpr, we mutagenized selected motifs with...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2002
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC136740/ https://ncbi.nlm.nih.gov/pubmed/12388729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.22.11704-11709.2002 |
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