Induction of Nitric Oxide Synthase-Dependent Telomere Shortening after Functional Inhibition of Hsp90 in Human Tumor Cells

In most cancer cells, the lengths of telomeres, the functional DNA-protein complexes located at chromosome ends, are maintained by the ribonucleoprotein telomerase. Hsp90 facilitates the assembly of telomerase and remains associated with the functional complex, implying a direct involvement of Hsp90...

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Bibliographic Details
Main Authors: Compton, Sarah A., Elmore, Lynne W., Haydu, Kimberly, Jackson-Cook, Colleen K., Holt, Shawn E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367181/
https://ncbi.nlm.nih.gov/pubmed/16449656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.4.1452-1462.2006
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