Loss of the Homotypic Fusion and Vacuole Protein Sorting or Golgi-Associated Retrograde Protein Vesicle Tethering Complexes Results in Gentamicin Sensitivity in the Yeast Saccharomyces cerevisiae

Gentamicin continues to be a primary antibiotic against gram-negative infections. Unfortunately, associated nephro- and ototoxicity limit its use. Our previous mammalian studies showed that gentamicin is trafficked to the endoplasmic reticulum in a retrograde manner and subsequently released into th...

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Detalhes bibliográficos
Main Authors: Wagner, Mark C., Molnar, Elizabeth E., Molitoris, Bruce A., Goebl, Mark G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366904/
https://ncbi.nlm.nih.gov/pubmed/16436714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.2.587-595.2006
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