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Functional Replacement of the Carboxy-Terminal Two-Thirds of the Influenza A Virus NS1 Protein with Short Heterologous Dimerization Domains

The NS1 protein of influenza A/WSN/33 virus is a 230-amino-acid-long protein which functions as an interferon alpha/beta (IFN-α/β) antagonist by preventing the synthesis of IFN during viral infection. In tissue culture, the IFN inhibitory function of the NS1 protein has been mapped to the RNA bindin...

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Udgivet i:J Virol
Principais autores: Wang, Xiuyan, Basler, Christopher F., Williams, Bryan R. G., Silverman, Robert H., Palese, Peter, García-Sastre, Adolfo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136679/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12438621/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.24.12951-12962.2002
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