The Role of Aspartic Acid 143 in E. coli tRNA-Guanine Transglycosylase: Insights from Mutagenesis Studies and Computational Modeling

tRNA guanine transglycosylase (TGT) is a tRNA-modifying enzyme which catalyzes the posttranscriptional exchange of guanine in position 34 of tRNA(Y,H,N,D) with the modified base queuine in eukaryotes or its precursor, preQ(1) base, in eubacteria. Thus, TGT must recognize the guanine in tRNA and the...

Full description

Saved in:
Bibliographic Details
Main Authors: Todorov, Katherine Abold, Tan, Xiao-Jian, Nonekowski, Susanne T., Garcia, George A., Carlson, Heather A.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2005
Subjects:
Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366699/
https://ncbi.nlm.nih.gov/pubmed/15951383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.059576
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items