The Role of Aspartic Acid 143 in E. coli tRNA-Guanine Transglycosylase: Insights from Mutagenesis Studies and Computational Modeling

tRNA guanine transglycosylase (TGT) is a tRNA-modifying enzyme which catalyzes the posttranscriptional exchange of guanine in position 34 of tRNA(Y,H,N,D) with the modified base queuine in eukaryotes or its precursor, preQ(1) base, in eubacteria. Thus, TGT must recognize the guanine in tRNA and the...

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Hlavní autoři: Todorov, Katherine Abold, Tan, Xiao-Jian, Nonekowski, Susanne T., Garcia, George A., Carlson, Heather A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Biophysical Society 2005
Témata:
Proteins
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366699/
https://ncbi.nlm.nih.gov/pubmed/15951383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.059576
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