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A Homology Model of the Pore Region of HCN Channels

HCN channels are activated by membrane hyperpolarization and regulated by cyclic nucleotides, such as cyclic adenosine-mono-phosphate (cAMP). Here we present structural models of the pore region of these channels obtained by using homology modeling and validated against spatial constraints derived f...

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Detalhes bibliográficos
Main Authors: Giorgetti, A., Carloni, P., Mistrik, P., Torre, V.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366642/
https://ncbi.nlm.nih.gov/pubmed/15951376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.045286
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