Brush Effects on DNA Chips: Thermodynamics, Kinetics, and Design Guidelines

In biology experiments, oligonucleotide microarrays are contacted with a solution of long nucleic acid targets. The hybridized probes thus carry long tails. When the surface density of the oligonucleotide probes is high enough, the progress of hybridization gives rise to a polyelectrolyte brush due...

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Bibliographic Details
Main Authors: Halperin, A., Buhot, A., Zhulina, E. B.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2005
Subjects:
Biophysical Theory and Modeling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366630/
https://ncbi.nlm.nih.gov/pubmed/15908581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.063479
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