Improved Hepatic Gene Transfer by Using an Adeno-Associated Virus Serotype 5 Vector

Adeno-associated viral (AAV) vectors have been shown to direct stable gene transfer and expression in hepatocytes, which makes them attractive tools for treatment of inherited disorders such as hemophilia B. While substantial levels of coagulation factor IX (F.IX) have been achieved using AAV seroty...

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Autores principales: Mingozzi, Federico, Schüttrumpf, Jörg, Arruda, Valder R., Liu, Yuhong, Liu, Yi-Lin, High, Katherine A., Xiao, Weidong, Herzog, Roland W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC136579/
https://ncbi.nlm.nih.gov/pubmed/12239326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.20.10497-10502.2002
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