BCL-2 and BAX Protect Adult Mice from Lethal Sindbis Virus Infection but Do Not Protect Spinal Cord Motor Neurons or Prevent Paralysis

Cellular proteins that regulate apoptotic cell death can modulate the outcome of Sindbis virus (SV) encephalitis in mice. Both endogenous and overexpressed BCL-2 and BAX proteins protect newborn mice from fatal SV infection by blocking apoptosis in infected neurons. To determine the effects of these...

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Autors principals: Kerr, Douglas A., Larsen, Thomas, Cook, Susan H., Fannjiang, Yih-Ru, Choi, Eunkyung, Griffin, Diane E., Hardwick, J. Marie, Irani, David N.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC136557/
https://ncbi.nlm.nih.gov/pubmed/12239316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.20.10393-10400.2002
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