BCL-2 and BAX Protect Adult Mice from Lethal Sindbis Virus Infection but Do Not Protect Spinal Cord Motor Neurons or Prevent Paralysis

Cellular proteins that regulate apoptotic cell death can modulate the outcome of Sindbis virus (SV) encephalitis in mice. Both endogenous and overexpressed BCL-2 and BAX proteins protect newborn mice from fatal SV infection by blocking apoptosis in infected neurons. To determine the effects of these...

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Detalhes bibliográficos
Main Authors: Kerr, Douglas A., Larsen, Thomas, Cook, Susan H., Fannjiang, Yih-Ru, Choi, Eunkyung, Griffin, Diane E., Hardwick, J. Marie, Irani, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136557/
https://ncbi.nlm.nih.gov/pubmed/12239316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.20.10393-10400.2002
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