Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine.

1. Fluvoxamine and seven other selective serotonin reuptake inhibitors (SRRI) were tested for their ability to inhibit a number of human cytochrome P450 isoforms (CYPs). 2. None of the drugs showed potent inhibition of CYP2A6 (coumarin 7-hydroxylase) or CYP2E1 (chlorzoxazone 6-hydroxylase), while no...

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Detalhes bibliográficos
Main Authors: Rasmussen, B B, Maënpää, J, Pelkonen, O, Loft, S, Poulsen, H E, Lykkesfeldt, J, Brøsen, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1364952/
https://ncbi.nlm.nih.gov/pubmed/7742153
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