Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.

In a previous study we showed that the disposition of clozapine after a single oral dose is unrelated to either debrisoquine or S-mephenytoin hydroxylation polymorphism. The same 14 healthy subjects studied in that investigation were given 150 mg of caffeine. The reciprocal of plasma clozapine AUC (...

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Главные авторы: Bertilsson, L, Carrillo, J A, Dahl, M L, Llerena, A, Alm, C, Bondesson, U, Lindström, L, Rodriguez de la Rubia, I, Ramos, S, Benitez, J
Формат: Artigo
Язык:Inglês
Опубликовано: 1994
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1364883/
https://ncbi.nlm.nih.gov/pubmed/7893591
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