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Pharmacokinetics of the enantiomers of bupivacaine following intravenous administration of the racemate.

1. The pharmacokinetics of R(+)-bupivacaine and S(-)-bupivacaine were investigated following a 10 min intravenous infusion of the racemate (dose 30 mg) in 10 healthy males. 2. The fractions unbound of R(+)- and S(-)-bupivacaine in pre-dose plasma were determined for each subject after in vitro addit...

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Detalhes bibliográficos
Main Authors: Burm, A G, van der Meer, A D, van Kleef, J W, Zeijlmans, P W, Groen, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1364857/
https://ncbi.nlm.nih.gov/pubmed/7981012
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